I was in San Francisco last month and heres the deal.
The Westin Hotel, Sir Francis Drake, Chancellor and my favourite, the Handlery hotel are all located on Union Square.
Union Square is the centre of San Francisco in terms of shopping. Macy's is on the Square, as is Tiffany's, Saks of 5th Avenue etc, basically its a shoppers haven. The Westfield shopping centre is 1 minute away and includes Bloomingdales amonst others.
The cable car runs along Union Square to Fishermans Wharf which is where you can see Pier 39, visit Alcatraz and sail out under the Golden Gate Bridge.
Any of the hotels mentioned above are ideal and literally yards from each other. Check out
www.expedia.ie and compare prices.
Also, when you arrive at San Francisco airport, go to the top floor and get the BART (Bay area rapid transport) train into the city centre. It takes about 20 mins, costs $5.75 and leaves you practically on Union Square.
Its cheap, safe and completely hassle free.
San Francisco is much more laid back than New York but in its own way, equally as impressive. Its very laid back and IMO a must for any traveller to have on their CV. Make sure you eat in the Cheesecake factory (its not actually a cheese cake factory!) on the top floor of Macy's and check out the Starlight Room nightclub on the 21st floor of the Sir Francis Drake hotel.