Hi
I have been to the US before on a road trip around New England with an 18th old, we are going to Orlando in March with same child who will be just 4. I think it depends on whether you get stressed with travelling on not. It doesn't bother me to bring him that distance at all. A good tip I saw was to wrap up one activity for every hour of the flight and that keeps them busy. I did pay the extra to get a direct flight though. I think that is worth it, otherwise it is just too much for them.
Re the camping, I doubt if they do anything by halves on that front. No Frontiers had a camper van park in Orlando on some time ago and it looked class, far better than what you would see in Europe.
I say go for it, god knows this is the time to be taking holidays if you can at all.