Do you have any children? In the event of that, can you afford the 300k mortgage as you will either have (a) childcare costs on top of the mortgage payments or (b) one parent will stay at home to mind small children. It's a very different world on one income, with kids than double income no kids.
There is also a psychological shift of course, going from a position of having a lot of lovely lolly in the bank to a position of owing a lot of lolly to the bank.