Higher yields in East Manchester, but goes with it the crime, dodgy tenants, DSS, unpaid rent, etc.
It was recently reported that East Manchester is the third most deprived area in the UK. Not surpirising, just take a drive there and its clear.
I would only buy in Manchester in the Southern suburbs - Chorlton, Didsbury, Withington, Fallowfield, etc. These are greenfield areas, where people want to live and will have difficulty to build too many new builds around due to the lack of available land.
The city centre is a no go, too many apartments, mostly empty. If you buy in the city centre make sure it is top end and very central. The places on the fringes of the city - castlefield, ancoats st, northern quater are hugely oversupplied.