Dinky said:
Well, if you take somewhere like Cork, for example (harbour port, airport, substantial and skilled population, more affordable accommodation and rents, less traffic congestion than Dublin), it seems that all these obstacles are easily surmountable. Infrastructure around Shannon is also improving, and it may well become a viable option in the very near future.
I see you're located in Cork, so you may have a vested interest eh? (Just kidding

).
Yeah, I don't see why Cork isn't a viable alternative, after all they have a university as well, and AFAIK, the airport is undergoing quite a bit of development as well, no?
If I'm not mistaken, Cork has the lion's share of Ireland's pharmaceutical industry, and so:
(a) maybe it makes sense to concentrate on deveoping that industry (e.g. through forging strong links between the NUI and industry); or
(b) seeking to diversify so the city is no longer dependent on pharmaceutical companies for employment/revenue.
One thing I would say about Cork is that it's quite remote and I think that many Oirish wouldn't be gone on the idea of locating there (I myself, being from Donegal originally wouldn't be keen unless they started a service from Cork airport to Carrickfinn), but that is something that could be changed in time I guess.
I think that the situation in the West is a little bit of a fudge. Shannon is near to Limerick and Galway, and these two cities will always be competing for investment against Shannon in that neck of the woods (as will Ennis for that matter). Shannon should be further developed IMHO. Once the N18 is dual carriageway, Shannon will be well within an hour of both Galway and Limerick and have it's own international airport (however small).