A couple of ideas which worked for us :
For my mum's 65th, the whole family (7 people) booked a beautiful villa in Portugal and had a great time. My parents were delighted to have a family holiday again, with us all grown-up this time.
For my mum's 70th, we put together a 'This is Your Life' book with anecdotes, stories, photos etc from loads of her friends, family, ex-work colleagues, people from her home town etc. She said that was one of her best presents ever, since it brought back so many memories.
Or maybe an exotic holiday somewhere - if they have always had a dream to go somewhere specific..